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Answer From Katherine Zeratsky, R.D., L.D. There is no solid evidence that cortisol blockers lead to weight loss. When you're under stress, your body boosts production of the hormone cortisol. Chronic stress and persistently high cortisol levels may be associated with increased appetite and weight gain. However, the connection between stress hormones and weight gain is largely based on anecdotal evidence, with only a few studies supporting it.
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