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J Pharm Sci. 2013 Jul;102(7):2120-7. Inhibitory effects of hesperetin derivatives on guinea pig phosphodiesterases and their ratios between high- and low-affinity rolipram binding.[Pubmed: 23666855] The phosphodiesterase (PDE)4 molecule exists as two distinct conformers, PDE4H and PDE4L , which have high and low affinities, respectively, for the selective PDE4 inhibitor, rolipram.
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The ketogenic diet involves a low carbohydrate intake, moderate protein intake and high fat intake. Reducing carbs and replacing them with healthy fats can cause your body to enter a metabolic state known as ketosis. Following the keto diet plan may be an effective method for weight loss.
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